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Home > Molecular Biology > Protein

Protease and Phosphatase Inhibitors for Cell Lysates

Reagent Target/Notes Stock Stock Preparation Final Concentration
Aprotinin protease Sigma n/a 1/100
Benzamidine competitive inhibitor of trypsin, trypsin-like enzymes, and serine proteases 250 mM 1 mM
Diisopropyl fluorophosphate protease 100mM 100mM in anhydrous 2-propanol. Powerful Neurotoxin 1mM
Iodoacetamide protease/phosphatase 500mM 93 mg/ml 5mM
Leupeptin protease 400 mM 200 mg/ml 4 mM
Na2EDTA (sodium EDTA) protease 500 mM pH 8.0 n/a chelates vanadate 5 mM
Na2EGTA (sodium EGTA) protease 500 mM pH8.0 n/a no vanadate chelation 5 mM
Na3VO4 (sodium vanadate) phosphatase 20-40mM 7.4 mg/ml 0.2-0.4mM
Na3VO4 (peroxide treated sodium vanadate) phosphatase 20mM 20mM Na3VO4, 15mM H2O2, 5min RT, then 200µg/ml catalase 0.2mM
NaF (sodium fluoride) phosphatase 1 M 42 mg/ml 10 mM
Na2MoO4 (sodium molybdate) phosphatase 1 M 242 mg/ml 10 mM
Na4P2O7 (sodium pyrophosphate) phosphatase 1 M 446 mg/ml 10 mM
Pepstatin A protease 100 µM 0.07 mg/ml in anhydrous 2-propanol 1 µM
PAO (phenylarsine oxide) phosphatase 100 mM 16.8 mg/ml in DMSO, serious contact hazard 50µM
PMSF (phenyl methyl sulfonyl) protease 100 mM 17.4 mg/ml in ethanol or in anhydrous 2-propanol 0.5-2 mM
Trypsin inhibitor protease 1 mg/ml 1 mg/ml 10 µg/ml